Huntingtin: Difference between revisions

Revision as of 10:03, 19 April 2020 view source Ivan Šonský (talk \| contribs) 75 edits No edit summary ← Older edit		Revision as of 10:06, 19 April 2020 view source Ivan Šonský (talk \| contribs) 75 edits No edit summary Newer edit →
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	HTT is mostly cytoplasmic. However, it can be aslo observed in the nucleus, as HTT comprises nuclear localization sequence in its NH2 terminus <ref>DOI 10.1074/jbc.M112.412379</ref>. Its nuclear localization implies for its role in transcription regulation. There are many transcription factors that were decribed to interact with mHTT. However, less known are the interactions with wild-type HTT. ~~Well known~~ gene ~~targetted by the~~ HTT-mediated transcription regulation is the brain derived nerve growth factor (BDNF) <ref>DOI 10.1038/ng1219</ref>.		HTT is mostly cytoplasmic. However, it can be aslo observed in the nucleus, as HTT comprises nuclear localization sequence in its NH2 terminus <ref>DOI 10.1074/jbc.M112.412379</ref>. Its nuclear localization implies for its role in transcription regulation. There are many transcription factors that were decribed to interact with mHTT. However, less known are the interactions with wild-type HTT. An example of a well described target gene of HTT-mediated transcription regulation is the brain derived nerve growth factor (BDNF) <ref>DOI 10.1038/ng1219</ref>.

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