Huntingtin: Difference between revisions

HTT is a 3144 amino acids comprising protein, which possesses the polyglutamine chain at the amino-terminal region. It also contains multiple consesnsus sequences called HEAT (huntingtin, elongation factor 3, protein phosphatase 2A, and TOR1 (target of rapamycin)) repeats. These HEAT repeats are very important for protein-protein interactions, of which HTT has plentiful. HEAT repeats consist of helix-turn-helix motifs, which are packed into a compact form of a superhelix hydrophobic core able to resist dissociation after proteolytic cleavage <ref>DOI 10.1074/jbc.M511007200</ref>.