Huntingtin: Difference between revisions

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HTT is a 3144 amino acids comprising protein, which possesses the polyglutamine chain at the amino-terminal region. It also contains multiple consesnsus sequences called HEAT (huntingtin, elongation factor 3, protein phosphatase 2A, and TOR1 (target of rapamycin)) repeats. These HEAT repeats are very important for protein-protein interactions, of which HTT has plentiful. HEAT repeats consist of helix-turn-helix motifs, which are packed into a compact form of a superhelix hydrophobic core able to resist dissociation upon proteolytic cleavage <ref>DOI 10.1074/jbc.M511007200</ref>. The presence of HEAT repeats enables HTT to participate in endocytosis-related trafficking thanks to clathrin and COPI (coat protein complex I) coatomer containing HEAT repeats as well.

HTT is a 3144 amino acids comprising protein, which possesses the polyglutamine chain at the amino-terminal region. It also contains multiple consesnsus sequences called HEAT (huntingtin, elongation factor 3, protein phosphatase 2A, and TOR1 (target of rapamycin)) repeats. These HEAT repeats are very important for protein-protein interactions, of which HTT has plentiful. HEAT repeats consist of helix-turn-helix motifs, which are packed into a compact form of a superhelix hydrophobic core able to resist dissociation upon proteolytic cleavage <ref>DOI 10.1074/jbc.M511007200</ref>. The presence of HEAT repeats enables HTT to participate in endocytosis-related trafficking thanks to clathrin and COPI (coat protein complex I) coatomer containing HEAT repeats as well <ref>DOI 10.1101/gr.147400</ref>.

== Disease ==

Huntingtin: Difference between revisions

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-HTT is a 3144 amino acids comprising protein, which possesses the polyglutamine chain at the amino-terminal region. It also contains multiple consesnsus sequences called HEAT (huntingtin, elongation factor 3, protein phosphatase 2A, and TOR1 (target of rapamycin)) repeats. These HEAT repeats are very important for protein-protein interactions, of which HTT has plentiful. HEAT repeats consist of helix-turn-helix motifs, which are packed into a compact form of a superhelix hydrophobic core able to resist dissociation upon proteolytic cleavage <ref>DOI 10.1074/jbc.M511007200</ref>. The presence of HEAT repeats enables HTT to participate in endocytosis-related trafficking thanks to clathrin and COPI (coat protein complex I) coatomer containing HEAT repeats as well.
+HTT is a 3144 amino acids comprising protein, which possesses the polyglutamine chain at the amino-terminal region. It also contains multiple consesnsus sequences called HEAT (huntingtin, elongation factor 3, protein phosphatase 2A, and TOR1 (target of rapamycin)) repeats. These HEAT repeats are very important for protein-protein interactions, of which HTT has plentiful. HEAT repeats consist of helix-turn-helix motifs, which are packed into a compact form of a superhelix hydrophobic core able to resist dissociation upon proteolytic cleavage <ref>DOI 10.1074/jbc.M511007200</ref>. The presence of HEAT repeats enables HTT to participate in endocytosis-related trafficking thanks to clathrin and COPI (coat protein complex I) coatomer containing HEAT repeats as well <ref>DOI 10.1101/gr.147400</ref>.
 == Disease ==