Sandbox Reserved 1627: Difference between revisions

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===Activation by Insulin===

Insulin is a [http://en.wikipedia.org/wiki/Peptide_hormone peptide hormone] produced and secreted from the [http://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans] of the pancreas in response to high blood glucose levels. Insulin is commonly considered the anabolic hormone of the body, and is ~~the~~ an important [http://en.wikipedia.org/wiki/Ligand ligand] in glucose homeostasis. The structure of <scene name='83/832953/Insulin_ligand/1'>insulin</scene> is a simple monomer composed of two peptide chains linked by intermolecular disulfide bridges. Without insulin, the glucose receptors cannot be brought to the surface of the membrane to take in excess glucose in the blood, which means they are inactive. The body has a mechanism in place to upregulate the production of insulin in the presence of a surplus of glucose circulating in the blood stream. The binding of the increased amount of insulin to the insulin receptors will activate their downstream pathways to initiate glucose uptake by the phosphorylation of the [http://en.wikipedia.org/wiki/Insulin_receptor_substrate Insulin Receptor Substrate] (IRS). The transport of extracellular glucose into the cell allows it to be converted to [http://en.wikipedia.org/wiki/Glycogen glycogen] for storage and later usage.

Insulin is a [http://en.wikipedia.org/wiki/Peptide_hormone peptide hormone] produced and secreted from the [http://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans] of the pancreas in response to high blood glucose levels. Insulin is commonly considered the anabolic hormone of the body, and is an important [http://en.wikipedia.org/wiki/Ligand ligand] in glucose homeostasis. The structure of <scene name='83/832953/Insulin_ligand/1'>insulin</scene> is a simple monomer composed of two peptide chains linked by intermolecular disulfide bridges. Without insulin, the glucose receptors cannot be brought to the surface of the membrane to take in excess glucose in the blood, which means they are inactive. The body has a mechanism in place to upregulate the production of insulin in the presence of a surplus of glucose circulating in the blood stream. The binding of the increased amount of insulin to the insulin receptors will activate their downstream pathways to initiate glucose uptake by the phosphorylation of the [http://en.wikipedia.org/wiki/Insulin_receptor_substrate Insulin Receptor Substrate] (IRS). The transport of extracellular glucose into the cell allows it to be converted to [http://en.wikipedia.org/wiki/Glycogen glycogen] for storage and later usage.

===Conformation Change===

Sandbox Reserved 1627: Difference between revisions

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 ===Activation by Insulin===
-Insulin is a [http://en.wikipedia.org/wiki/Peptide_hormone peptide hormone] produced and secreted from the [http://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans] of the pancreas in response to high blood glucose levels. Insulin is commonly considered the anabolic hormone of the body, and is the an important [http://en.wikipedia.org/wiki/Ligand ligand] in glucose homeostasis. The structure of <scene name='83/832953/Insulin_ligand/1'>insulin</scene> is a simple monomer composed of two peptide chains linked by intermolecular disulfide bridges. Without insulin, the glucose receptors cannot be brought to the surface of the membrane to take in excess glucose in the blood, which means they are inactive. The body has a mechanism in place to upregulate the production of insulin in the presence of a surplus of glucose circulating in the blood stream. The binding of the increased amount of insulin to the insulin receptors will activate their downstream pathways to initiate glucose uptake by the phosphorylation of the [http://en.wikipedia.org/wiki/Insulin_receptor_substrate Insulin Receptor Substrate] (IRS). The transport of extracellular glucose into the cell allows it to be converted to [http://en.wikipedia.org/wiki/Glycogen glycogen] for storage and later usage.
+Insulin is a [http://en.wikipedia.org/wiki/Peptide_hormone peptide hormone] produced and secreted from the [http://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans] of the pancreas in response to high blood glucose levels. Insulin is commonly considered the anabolic hormone of the body, and is an important [http://en.wikipedia.org/wiki/Ligand ligand] in glucose homeostasis. The structure of <scene name='83/832953/Insulin_ligand/1'>insulin</scene> is a simple monomer composed of two peptide chains linked by intermolecular disulfide bridges. Without insulin, the glucose receptors cannot be brought to the surface of the membrane to take in excess glucose in the blood, which means they are inactive. The body has a mechanism in place to upregulate the production of insulin in the presence of a surplus of glucose circulating in the blood stream. The binding of the increased amount of insulin to the insulin receptors will activate their downstream pathways to initiate glucose uptake by the phosphorylation of the [http://en.wikipedia.org/wiki/Insulin_receptor_substrate Insulin Receptor Substrate] (IRS). The transport of extracellular glucose into the cell allows it to be converted to [http://en.wikipedia.org/wiki/Glycogen glycogen] for storage and later usage.
 ===Conformation Change===