Sandbox Reserved 1627: Difference between revisions
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[[Image:4 sites highlighted - Harrison.png|thumb|right|260px|Figure 2: The four binding sites of insulin. Sites 1 and 1' are colored green, sites 2 and 2' are colored red. [http://www.rcsb.org/structure/6SOF PDB 6SOF]]] | [[Image:4 sites highlighted - Harrison.png|thumb|right|260px|Figure 2: The four binding sites of insulin. Sites 1 and 1' are colored green, sites 2 and 2' are colored red. [http://www.rcsb.org/structure/6SOF PDB 6SOF]]] | ||
===Beta Subunits=== | ===Beta Subunits=== | ||
The beta subunit spans from the extracellular domain across the transmembrane region and into the intracellular portion of the insulin receptor. The beta subunit is composed of part of [http://en.wikipedia.org/wiki/Fibronectin fibronectin] domain III-2 and all of Fibronectin domain III-3. <ref name="Scapin" /> The beta subunit's FnIII-3 domain has links through the transmembrane region into the intracellular part of the membrane.[http://en.wikipedia.org/wiki/Transmission_electron_cryomicroscopy Cryo-EM] results have displayed clear representations of FnIII-2 and FnIII-3 domains, but lack in their ability to model the receptor structure throughout the transmembrane region and intracellular region. Although, the FnIII-3 domain is connected to these regions, so it has been proposed that the T-shape conformation extends all the way to the tyrosine kinase domain region. [http://www.rcsb.org/structure/4XLV PDB 4XLV] <ref name= "Cabail"> DOI: 10.1038/ncomms7406 </ref> | The beta subunit spans from the extracellular domain across the transmembrane region and into the intracellular portion of the insulin receptor. The beta subunit is composed of part of [http://en.wikipedia.org/wiki/Fibronectin fibronectin] domain III-2 and all of Fibronectin domain III-3. <ref name="Scapin" /> The beta subunit's FnIII-3 domain has links through the transmembrane region into the intracellular part of the membrane.[http://en.wikipedia.org/wiki/Transmission_electron_cryomicroscopy Cryo-EM] results have displayed clear representations of FnIII-2 and FnIII-3 domains, but lack in their ability to model the receptor structure throughout the transmembrane region and intracellular region. Although, the FnIII-3 domain is connected to these regions, so it has been proposed that the T-shape conformation extends all the way to the tyrosine kinase domain region. (see [http://www.rcsb.org/structure/4XLV PDB 4XLV]). <ref name= "Cabail"> DOI: 10.1038/ncomms7406 </ref> | ||
== Function== | == Function== | ||
