Sandbox Reserved 1600: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Emma Harris (talk | contribs) No edit summary |
Emma Harris (talk | contribs) No edit summary |
||
| Line 47: | Line 47: | ||
When all of these elements of the reduction aggregate in the active site, the protons and electrons are shuttled to <scene name='83/838655/Bd_oxidase_heme_d/1'>Heme D</scene>, where the actual reduction occurs. The 2H₂O molecules are then expelled, as seen in <font color='red'><b>red</b></font> in Figure 4. The shuttling of these electrons and protons also helps assist with the electric chemical potential in the [https://en.wikipedia.org/wiki/Cell_membrane cellular membrane]. | When all of these elements of the reduction aggregate in the active site, the protons and electrons are shuttled to <scene name='83/838655/Bd_oxidase_heme_d/1'>Heme D</scene>, where the actual reduction occurs. The 2H₂O molecules are then expelled, as seen in <font color='red'><b>red</b></font> in Figure 4. The shuttling of these electrons and protons also helps assist with the electric chemical potential in the [https://en.wikipedia.org/wiki/Cell_membrane cellular membrane]. | ||
= Structure Similarity to bd oxidase found in ''E. coli'' = | = Structure Similarity to bd oxidase found in ''E. coli'' = | ||
| Line 56: | Line 52: | ||
</StructureSection> | </StructureSection> | ||
= Biological Importance of O₂ reduction = | |||
Oxygen toxicity is a fatal problem among all organisms, but can easily occur in prokaryotes due to their low oxygen tolerance. In prokaryotes, the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171616/ cytochrome bd oxygen reductases] function to quickly reduce the concentration of O₂ into H₂O to protect the cell from detrimental effects. Without proper functioning of these enzymes, or if O₂ concentrations are too high, the concentrations of the intermediates formed from the reduction reaction will increase and can be detrimental. As a result of the vitality of reducing O₂ in prokaryotes, knowledge on bd oxidases can help develop drugs that target these enzymes to combat bacterial infection.<ref name=”Borisov”>PMID:21756872</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
