Sandbox Reserved 1607: Difference between revisions

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===Selectivity Filter===

The <scene name='83/832933/Selectivity_filter/3'>selectivity filter</scene> contains Glu358, Trp354, and Pro359 to allow calcium to pass through the uniporter. The carboxylate oxygen of the <scene name='83/832933/Glu_358/3'>Glu358</scene> side chains draw in the positive calcium ion. The <scene name='83/832933/Diameter/2'>diameter</scene> of the carboxyl ring is about 4Å, allowing only a dehydrated Ca2+ ion to bind. Trp38, which is directly next to the Glu residues, stabilizes the carbonyl side chains through <scene name='83/832933/H_bond_trp354_glu358/3'>hydrogen bonding</scene> and anion pi interactions. These Trp residues also form stacking interactions with Pro359, which orientate the Glu carboxyl side chains towards the middle of the pore to interact with Ca2+ ions. <ref name=”Yoo”>PMID:29954988</ref>

The <scene name='83/832933/Selectivity_filter/3'>selectivity filter</scene> contains <scene name='83/832933/Glu_residues_all/1'>Glu358</scene>, Trp354, and Pro359 to allow calcium to pass through the uniporter. The carboxylate oxygen of the <scene name='83/832933/Glu_358/3'>Glu358</scene> side chains draw in the positive calcium ion. The <scene name='83/832933/Diameter/2'>diameter</scene> of the carboxyl ring is about 4Å, allowing only a dehydrated Ca2+ ion to bind. Trp38, which is directly next to the Glu residues, stabilizes the carbonyl side chains through <scene name='83/832933/H_bond_trp354_glu358/3'>hydrogen bonding</scene> and anion pi interactions. These Trp residues also form stacking interactions with Pro359, which orientate the Glu carboxyl side chains towards the middle of the pore to interact with Ca2+ ions. <ref name=”Yoo”>PMID:29954988</ref>

[http://www.rcsb.org/structure/6DT0 Calcium Uniporter Structure]

Sandbox Reserved 1607: Difference between revisions

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@@ Line 18: / Line 18: @@
 ===Selectivity Filter===
-The <scene name='83/832933/Selectivity_filter/3'>selectivity filter</scene> contains Glu358, Trp354, and Pro359 to allow calcium to pass through the uniporter. The carboxylate oxygen of the <scene name='83/832933/Glu_358/3'>Glu358</scene> side chains draw in the positive calcium ion. The <scene name='83/832933/Diameter/2'>diameter</scene> of the carboxyl ring is about 4Å, allowing only a dehydrated Ca2+ ion to bind. Trp38, which is directly next to the Glu residues, stabilizes the carbonyl side chains through <scene name='83/832933/H_bond_trp354_glu358/3'>hydrogen bonding</scene> and anion pi interactions. These Trp residues also form stacking interactions with Pro359, which orientate the Glu carboxyl side chains towards the middle of the pore to interact with Ca2+ ions. <ref name=”Yoo”>PMID:29954988</ref>
+The <scene name='83/832933/Selectivity_filter/3'>selectivity filter</scene> contains <scene name='83/832933/Glu_residues_all/1'>Glu358</scene>, Trp354, and Pro359 to allow calcium to pass through the uniporter. The carboxylate oxygen of the <scene name='83/832933/Glu_358/3'>Glu358</scene> side chains draw in the positive calcium ion. The <scene name='83/832933/Diameter/2'>diameter</scene> of the carboxyl ring is about 4Å, allowing only a dehydrated Ca2+ ion to bind. Trp38, which is directly next to the Glu residues, stabilizes the carbonyl side chains through <scene name='83/832933/H_bond_trp354_glu358/3'>hydrogen bonding</scene> and anion pi interactions. These Trp residues also form stacking interactions with Pro359, which orientate the Glu carboxyl side chains towards the middle of the pore to interact with Ca2+ ions. <ref name=”Yoo”>PMID:29954988</ref>
 [http://www.rcsb.org/structure/6DT0 Calcium Uniporter Structure]