Sandbox Reserved 1626: Difference between revisions

Calcium homeostasis dysregulation has also been proven to be instrumental in [https://en.wikipedia.org/wiki/Obesity obesity], [https://en.wikipedia.org/wiki/Insulin_resistance insulin resistance], and [https://en.wikipedia.org/wiki/Type_2_diabetes type-II diabetes].<ref name="Wang"/> The intracellular calcium concentrations in primary [https://en.wikipedia.org/wiki/Adipocyte adipocytes] from obese human subjects was found to be elevated.<ref name="Wang"/> Any inhbition of downstream calcium signaling could decrease movement of the [http://proteopedia.org/wiki/index.php/GLUT4 GLUT4] glucose transporter and glucose uptake.<ref name="Wang"/> Additionally, [https://en.wikipedia.org/wiki/Ablation ablation] of MCU in [https://en.wikipedia.org/wiki/Beta_cell β-cells] in the [https://en.wikipedia.org/wiki/Pancreas pancreas] demonstrated a decrease in cellular ATP concentration following glucose stimulation which resulted in decreased glucose-stimulated insulin secretion.<ref name="Wang"/>  Furthermore, MAMs have been shown to cause glucose intolerance and mitochondrial dysfunction in primary [https://en.wikipedia.org/wiki/Hepatocyte hepatocytes] in mice.<ref name="Wang"/> Subsequent reinforcement of these MAMs has been shown to increase insulin sensitivity and glucose homeostasis.<ref name="Wang"/>