Sandbox Reserved 1613: Difference between revisions

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===Transmembrane Domains===

In the transmembrane domain is located the leucine plug that separates the first site of binding from the second site of binding for the substrate. Both domains are stabilized by several interactions both intermolecularly. The first and most prominent feature of the TMD is EL-3. This loop which extends out from the transmembrane domain has been shown to be involved in stabilization of the TMD's. A member of the same subfamily, ABCG5/ABCG8, was shown to have <scene name='83/832939/El-3_of_abcg5_abcg8/1'>EL-3 helices</scene> that extended further into the extracellular space. This condensed helices is one of the defining features of ABCG2 transporter protein.

In the transmembrane domain is located the leucine plug that separates the first site of binding from the second site of binding for the substrate. Both domains are stabilized by several interactions both intermolecularly. The first and most prominent feature of the TMD is EL-3. This loop which extends out from the transmembrane domain has been shown to be involved in stabilization of the TMD's. A member of the same subfamily, ABCG5/ABCG8, was shown to have <scene name='83/832939/El-3_of_abcg5_abcg8/1'>EL-3 helices</scene> that extended further into the extracellular space. This condensed helices is one of the defining features of ABCG2 transporter protein. The EL-3 of ABCG2 is stabilized by both intermolecular and intramolecular disulfide bonds.

===Nucleotide Binding Domains===

These two domains contain the active site of this transporter protein. The interest in this protein is in its involvement with mutidrug resistant cancer cells. This involvement is due to its active site's promiscuity as many xenobiotics have been found to transported to the outside of the cell by this transporter.

Sandbox Reserved 1613: Difference between revisions

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@@ Line 22: / Line 22: @@
 <ref name="Manolaridis">PMID:30405239</ref>
 ===Transmembrane Domains===
-In the transmembrane domain is located the leucine plug that separates the first site of binding from the second site of binding for the substrate. Both domains are stabilized by several interactions both intermolecularly. The first and most prominent feature of the TMD is EL-3. This loop which extends out from the transmembrane domain has been shown to be involved in stabilization of the TMD's. A member of the same subfamily, ABCG5/ABCG8, was shown to have <scene name='83/832939/El-3_of_abcg5_abcg8/1'>EL-3 helices</scene> that extended further into the extracellular space. This condensed helices is one of the defining features of ABCG2 transporter protein.
+In the transmembrane domain is located the leucine plug that separates the first site of binding from the second site of binding for the substrate. Both domains are stabilized by several interactions both intermolecularly. The first and most prominent feature of the TMD is EL-3. This loop which extends out from the transmembrane domain has been shown to be involved in stabilization of the TMD's. A member of the same subfamily, ABCG5/ABCG8, was shown to have <scene name='83/832939/El-3_of_abcg5_abcg8/1'>EL-3 helices</scene> that extended further into the extracellular space. This condensed helices is one of the defining features of ABCG2 transporter protein. The EL-3 of ABCG2 is stabilized by both intermolecular and intramolecular disulfide bonds.
 ===Nucleotide Binding Domains===
 These two domains contain the active site of this transporter protein. The interest in this protein is in its involvement with mutidrug resistant cancer cells. This involvement is due to its active site's promiscuity as many xenobiotics have been found to transported to the outside of the cell by this transporter.