Epsin: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> describing Jmol <ref>PMID:21638687</ref> to the rescue. == Function == == Disease ==... |
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<StructureSection load='5on7' size='340' side='right' caption='Caption for this structure' scene=''> | |||
== Function == | |||
'''Epsin''' (Eps) is essential for cell viability in yeast and for embryo development in higher eukaryotes. Epsins function as adaptors by recognizing ubiquitinated cargo and as endocytic accessory proteins by contributing to endocytic network stability regulation and membrane bending<ref>PMID:22942912</ref>. The N-terminus domain of Eps is called Epsin N-Terminal Homology domain (ENTH). ENTH is a highly conserved ca. 150 amino acid-long domain which binds phosphatidylinoitol 4,5-bisphosphate which is a lipid enriched at regions of plasma membrane including endocytic sites. | |||
== Disease == | == Disease == | ||
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[[5lp0]] - Eps-1 ENTH domain - zebrafish<br /> | [[5lp0]] - Eps-1 ENTH domain - zebrafish<br /> | ||
[[5onf]], [[5loz]] - yEps-1 ENTH domain - yeast<br /> | [[5onf]], [[5loz]] - yEps-1 ENTH domain - yeast<br /> | ||
[[5ahv]] - yEps-1 ENTH domain + SLA2 ANTH domain - | [[5ahv]] - yEps-1 ENTH domain + SLA2 ANTH domain - Cryo EM<br /> | ||
[[6enr]], [[4gzc]] - yEps-2 ENTH domain<br /> | [[6enr]], [[4gzc]] - yEps-2 ENTH domain<br /> | ||
[[4gzd]] - yEps-2 ENTH domain (mutant)<br /> | [[4gzd]] - yEps-2 ENTH domain (mutant)<br /> | ||
