Sandbox Reserved 895: Difference between revisions
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RPE65 is a known retinoid isomerohydrolase (IMH). In the visual cycle RPE65 catalyzes both an isomerization reaction which converts a ''trans'' double bond at carbon-11 to a ''cis'' configuration as well as a hydrolysis reaction that converts an ester functional group (the retinyl ester) into an alcohol functional group and a carboxylic acid using water. The catalyzed reaction is the rate limiting step in the retinoid cycle. '''Figure 3''' shows the reaction schema. <ref> DOI 25894083 </ref> | RPE65 is a known retinoid isomerohydrolase (IMH). In the visual cycle RPE65 catalyzes both an isomerization reaction which converts a ''trans'' double bond at carbon-11 to a ''cis'' configuration as well as a hydrolysis reaction that converts an ester functional group (the retinyl ester) into an alcohol functional group and a carboxylic acid using water. The catalyzed reaction is the rate limiting step in the retinoid cycle. '''Figure 3''' shows the reaction schema. <ref> DOI 25894083 </ref> | ||
[[Image: | [[Image:RPE65_reaction_schema.jpg|thumb|center|512 px|alt=Figure 3: RPE65 reaction schema| '''Figure 3:''' RPE65 Catalyzed Reaction Schema <ref> DOI 25894083 </ref>]] | ||
=== '''[1.2.1] Classification of RPE65''' === | === '''[1.2.1] Classification of RPE65''' === | ||
