Huntingtin: Difference between revisions
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Wild-type HTT is well known for its scaffolding function. It interacts with β-tubulin and binds to microtubules. Besides, it interacts with the dynein/dynactin complex, thereby regulating vesicular transport <ref>DOI 10.1073/pnas.0610628104</ref>. Furthermore, HTT has been shown to localize to spindle poles during mitosis, regulating spindle orientation in mouse neuronal cells<ref>DOI 10.1016/j.neuron.2010.06.027</ref>. On the other hand, the abnormal scaffolding function for molecular motors operated via mHTT results in abrupted axonal transport. That leads to inefficient distribution of mitochondria within nerve cells, causing low <ref>DOI 10.1007/s11062-013-9341-1</ref> | Wild-type HTT is well known for its scaffolding function. It interacts with β-tubulin and binds to microtubules. Besides, it interacts with the dynein/dynactin complex, thereby regulating vesicular transport <ref>DOI 10.1073/pnas.0610628104</ref>. Furthermore, HTT has been shown to localize to spindle poles during mitosis, regulating spindle orientation in mouse neuronal cells<ref>DOI 10.1016/j.neuron.2010.06.027</ref>. On the other hand, the abnormal scaffolding function for molecular motors operated via mHTT results in abrupted axonal transport. That leads to inefficient distribution of mitochondria within nerve cells, causing low transfer of energy at places like synapses <ref>DOI 10.1007/s11062-013-9341-1</ref> | ||
'''Huntingtin Protein and Autophagy''' | '''Huntingtin Protein and Autophagy''' | ||
