Vm24 Scorpion Toxin: Difference between revisions
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Positions <scene name='84/842913/Resi_7-9/1'>7-9</scene> and <scene name='84/842913/Resi_17-20/1'>17-20</scene> are not well defined because they have a reduced number of Nuclear Overhauser effects NOEs [https://pubmed-ncbi-nlm-nih-gov.ezproxy.uvm.edu/22540187/?from_single_result=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.&expanded_search_query=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.] All <scene name='84/842913/All_disulfides/2'>cysteines</scene> and <scene name='84/842913/Ile4/1'>Ile4</scene> are buried entirely, but all other residues are exposed. <scene name='84/842913/Tyr35/1'>Tyr35</scene> and <scene name='84/842913/Cys36/1'>Cys36</scene> are in a very flexible region, which is interesting because they are adjacent to a <scene name='84/842913/Ssbonds_21-36/1'>disulfide bridge</scene>. | Positions <scene name='84/842913/Resi_7-9/1'>7-9</scene> and <scene name='84/842913/Resi_17-20/1'>17-20</scene> are not well defined because they have a reduced number of Nuclear Overhauser effects NOEs [https://pubmed-ncbi-nlm-nih-gov.ezproxy.uvm.edu/22540187/?from_single_result=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.&expanded_search_query=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.] All <scene name='84/842913/All_disulfides/2'>cysteines</scene> and <scene name='84/842913/Ile4/1'>Ile4</scene> are buried entirely, but all other residues are exposed. <scene name='84/842913/Tyr35/1'>Tyr35</scene> and <scene name='84/842913/Cys36/1'>Cys36</scene> are in a very flexible region, which is interesting because they are adjacent to a <scene name='84/842913/Ssbonds_21-36/1'>disulfide bridge</scene>. | ||
==Function== | ==Function== | ||
Vm24 is a potent and selective inhibitor of Kv1.3 potassium channels of human T lymphocytes. In vitro, Kv1.3 current is reduced by approximately 2/3 < | Vm24 is a potent and selective inhibitor of Kv1.3 potassium channels of human T lymphocytes. In vitro, Kv1.3 current is reduced by approximately 2/3 <sub>rds in the presence of 3pM of Vm24 | ||
