Vm24 Scorpion Toxin: Difference between revisions

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Vm24 has about 1500 fold selectivity for Kv1.3 over the 10 other ion channels tested.

==Medical Relevance==

Proliferation of T- cells can be blocked by blocking membrane K+ channels. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases.

Proliferation of T- cells can be blocked by blocking membrane K+ channels[https://www.pnas.org/content/96/19/10917]. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases.

Vm24 Scorpion Toxin: Difference between revisions

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@@ Line 18: / Line 18: @@
 Vm24 has about 1500 fold selectivity for Kv1.3 over the 10 other ion channels tested.
 ==Medical Relevance==
-Proliferation of T- cells can be blocked by blocking membrane K+ channels. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases.
+Proliferation of T- cells can be blocked by blocking membrane K+ channels[https://www.pnas.org/content/96/19/10917]. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases.