1b86: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1b86.gif|left|200px]]
[[Image:1b86.gif|left|200px]]


{{Structure
<!--
|PDB= 1b86 |SIZE=350|CAPTION= <scene name='initialview01'>1b86</scene>, resolution 2.5&Aring;
The line below this paragraph, containing "STRUCTURE_1b86", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DDH:[7,12-DEACETYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(2-)-N21,N22,N23,N24]-IRON'>DDH</scene>, <scene name='pdbligand=DG2:2,3-DIPHOSPHOGLYCERIC+ACID'>DG2</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1b86| PDB=1b86  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b86 OCA], [http://www.ebi.ac.uk/pdbsum/1b86 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b86 RCSB]</span>
}}


'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''
'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''
Line 28: Line 25:
[[Category: Mauguen, Y.]]
[[Category: Mauguen, Y.]]
[[Category: Richard, V.]]
[[Category: Richard, V.]]
[[Category: 2]]
[[Category: 3-diphosphoglycerate]]
[[Category: 3-diphosphoglycerate]]
[[Category: allosteric effector]]
[[Category: Allosteric effector]]
[[Category: haemoglobin]]
[[Category: Haemoglobin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:11:28 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:55:34 2008''

Revision as of 08:11, 2 May 2008

File:1b86.gif

Template:STRUCTURE 1b86

HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX


Overview

The haemoglobin-2,3-diphosphoglycerate complex structure has been solved at 2.5 A resolution using crystals grown from low-salt solutions. The results show some important differences with the precedent haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone. First, we observe a loss of symmetry in the binding site, secondly both of the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the same time, each making two contacts. This level of interaction is in agreement with the functional behaviour of natural haemoglobin mutants with mutations at the 2,3-diphosphoglycerate binding site.

About this Structure

1B86 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution., Richard V, Dodson GG, Mauguen Y, J Mol Biol. 1993 Sep 20;233(2):270-4. PMID:8377203 Page seeded by OCA on Fri May 2 11:11:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1b86&oldid=320416"