5ffy: Difference between revisions
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==Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand== | ==Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand== | ||
<StructureSection load='5ffy' size='340' side='right' caption='[[5ffy]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='5ffy' size='340' side='right'caption='[[5ffy]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ffy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFY OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[5ffy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FFY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XD:4-ETHYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)BENZENESULFONAMIDE'>5XD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XD:4-ETHYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)BENZENESULFONAMIDE'>5XD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ffy OCA], [http://pdbe.org/5ffy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ffy RCSB], [http://www.ebi.ac.uk/pdbsum/5ffy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ffy ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | [[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
==See Also== | |||
*[[Peregrin|Peregrin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 07:17, 6 May 2020
Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand
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