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| <StructureSection load='1www' size='340' side='right' caption='Human NGF (pink, yellow) complex with glycosylated TrkA receptor (grey, green) (PDB code [[2ifg]])' scene=''> | | <StructureSection load='1www' size='340' side='right' caption='Human NGF (purple, khaki) complex with TrkA receptor domain 5 (azure, mustard) (PDB code [[1www]])' scene=''> |
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| == Function == | | == Function == |
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| == Structural highlights == | | == Structural highlights == |
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| The 3D structure of the complex between human NGF and one of its receptors - TrkA - is shaped like a crab with the NGF homodimer serving as the crab's body. | | The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the receptor D-5 domain Ig-like structure flanking the NGF homodimer. Various side chains form the interaction between NGF and its receptor with a totally buried NGF Arg residue forming the strongest one<ref>PMID:10490030</ref>. |
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| </StructureSection> | | </StructureSection> |
Revision as of 10:20, 13 May 2020
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Function
Nerve growth factor (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions[1]. NGF interacts with 2 transmembrane receptors - TrkA and p75.
Relevance
Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker[2].
Structural highlights
The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the receptor D-5 domain Ig-like structure flanking the NGF homodimer. Various side chains form the interaction between NGF and its receptor with a totally buried NGF Arg residue forming the strongest one[3].
- ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:https://dx.doi.org/10.1146/annurev.neuro.24.1.1217
- ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:https://dx.doi.org/10.3389/fnins.2019.00533
- ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705
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3D structures of nerve growth factor
Updated on 13-May-2020
4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra
References
