Sandbox Reserved 1621: Difference between revisions

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===Overall Structure===

GS is composed of 20 transmembrane components (TMs) and has four separate protein subunits: '''Nicastran (NCT), Presenilin (PS1), Anterior Pharynx-defective 1 (APH-1),''' and '''Presenilin Enhancer 2 (PEN-2).'''<ref name="Bai_2015">PMID:26623517</ref> These subunits are stabilized as functional GS by hydrophobic interactions and 4 [https://en.wikipedia.org/wiki/Phosphatidylcholine phosphatidylcholines]~~.These <scene name='83/832945/Phosphotidylcholines/2'>phosphatidylcholines</scene> have interfaces between: PS1 and PEN-2, APH-1 and PS1, APH-1 and NCT~~.

GS is composed of 20 transmembrane components (TMs) and has four separate protein subunits: '''Nicastran (NCT), Presenilin (PS1), Anterior Pharynx-defective 1 (APH-1),''' and '''Presenilin Enhancer 2 (PEN-2).'''<ref name="Bai_2015">PMID:26623517</ref> These subunits are stabilized as functional GS by predominately hydrophobic interactions and four [https://en.wikipedia.org/wiki/Phosphatidylcholine phosphatidylcholines].

<scene name='83/832945/Nct_subunit_shown/1'>NCT</scene> has a large extracellular domain and one TM. NCT is important to substrate recognition and binding.

<scene name='83/832945/Ps1_subunit/1'>PS1</scene> serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between <scene name='83/832945/Tm6_and_tm7/1'>TM6 and TM7</scene> of PS1 and a major conformational changes take place in the PS1 subunit upon substrate binding.

<scene name='83/832945/Ps1_subunit/1'>PS1</scene> serves as the active site of the protease and contains nine TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between <scene name='83/832945/Tm6_and_tm7/2'>TM6 and TM7</scene> of PS1 and a major conformational changes take place in the PS1 subunit upon substrate binding.

<scene name='83/832945/Aph-1_subunit/1'>APH-1</scene> serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1.

Activation of the active site is dependent on the binding of <scene name='83/832945/Pen2_subunit/1'>PEN-2</scene>. PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref>

Activation of the active site is dependent on the binding of <scene name='83/832945/Pen2_subunit/1'>PEN-2</scene>. PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref> Finally, the five <scene name='83/832945/Phosphotidylcholines/3'>phosphatidylcholines</scene> reside in the following subunit interfaces between: PS1 and PEN-2, APH-1 and PS1, APH-1 and NCT.

== Structural highlights ==

Sandbox Reserved 1621: Difference between revisions

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@@ Line 7: / Line 7: @@
 ===Overall Structure===
-GS is composed of 20 transmembrane components (TMs) and has four separate protein subunits: '''<font color='lightsteelblue'>Nicastran (NCT)</font>, <font color='lightgreen'>Presenilin (PS1)</font>, <font color= 'pink'>Anterior Pharynx-defective 1 (APH-1)</font>,''' and '''<font color='khaki'>Presenilin Enhancer 2 (PEN-2).</font>'''<ref name="Bai_2015">PMID:26623517</ref> These subunits are stabilized as functional GS by hydrophobic interactions and 4 [https://en.wikipedia.org/wiki/Phosphatidylcholine phosphatidylcholines].These <scene name='83/832945/Phosphotidylcholines/2'>phosphatidylcholines</scene> have interfaces between: PS1 and PEN-2, APH-1 and PS1, APH-1 and NCT.
+GS is composed of 20 transmembrane components (TMs) and has four separate protein subunits: '''<font color='lightsteelblue'>Nicastran (NCT)</font>, <font color='lightgreen'>Presenilin (PS1)</font>, <font color= 'pink'>Anterior Pharynx-defective 1 (APH-1)</font>,''' and '''<font color='khaki'>Presenilin Enhancer 2 (PEN-2).</font>'''<ref name="Bai_2015">PMID:26623517</ref> These subunits are stabilized as functional GS by predominately hydrophobic interactions and four [https://en.wikipedia.org/wiki/Phosphatidylcholine phosphatidylcholines].
 <scene name='83/832945/Nct_subunit_shown/1'>NCT</scene> has a large extracellular domain and one TM. NCT is important to substrate recognition and binding.
-<scene name='83/832945/Ps1_subunit/1'>PS1</scene> serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between <scene name='83/832945/Tm6_and_tm7/1'>TM6 and TM7</scene> of PS1 and a major conformational changes take place in the PS1 subunit upon substrate binding.
+<scene name='83/832945/Ps1_subunit/1'>PS1</scene> serves as the active site of the protease and contains nine TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between <scene name='83/832945/Tm6_and_tm7/2'>TM6 and TM7</scene> of PS1 and a major conformational changes take place in the PS1 subunit upon substrate binding.
 <scene name='83/832945/Aph-1_subunit/1'>APH-1</scene> serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1.
-Activation of the active site is dependent on the binding of <scene name='83/832945/Pen2_subunit/1'>PEN-2</scene>. PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref>
+Activation of the active site is dependent on the binding of <scene name='83/832945/Pen2_subunit/1'>PEN-2</scene>. PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref> Finally, the five <scene name='83/832945/Phosphotidylcholines/3'>phosphatidylcholines</scene> reside in the following subunit interfaces between: PS1 and PEN-2, APH-1 and PS1, APH-1 and NCT.
 == Structural highlights ==