1bc7: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:1bc7.gif|left|200px]]
[[Image:1bc7.gif|left|200px]]


{{Structure
<!--
|PDB= 1bc7 |SIZE=350|CAPTION= <scene name='initialview01'>1bc7</scene>, resolution 2.01&Aring;
The line below this paragraph, containing "STRUCTURE_1bc7", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= SAP-1 RESIDUES 1-93 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_1bc7| PDB=1bc7  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bc7 OCA], [http://www.ebi.ac.uk/pdbsum/1bc7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bc7 RCSB]</span>
}}


'''SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX'''
'''SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX'''
Line 29: Line 26:
[[Category: Mo, Y.]]
[[Category: Mo, Y.]]
[[Category: Vaessen, B.]]
[[Category: Vaessen, B.]]
[[Category: complex (dna-binding protein/dna)]]
[[Category: Crystal structure]]
[[Category: crystal structure]]
[[Category: Dna-binding domain]]
[[Category: dna-binding domain]]
[[Category: Dna-binding specificity]]
[[Category: dna-binding specificity]]
[[Category: Ets domain]]
[[Category: ets domain]]
[[Category: Winged helix-turn-helix]]
[[Category: winged helix-turn-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:19:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:57:58 2008''

Revision as of 08:19, 2 May 2008

File:1bc7.gif

Template:STRUCTURE 1bc7

SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX


Overview

SAP-1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c-fos protooncogene. The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. Discrimination for sequences outside this core is mediated by DNA contacts from conserved and nonconserved protein residues and sequence-dependent DNA structural properties characteristic of A-form DNA structure. Comparison with the related PU.1/DNA and GABPalpha/beta/DNA complexes provides general insights into DNA discrimination between Ets proteins. Modeling studies of a SAP-1/SRF/DNA complex suggest that SRF may modulate SAP-1 binding to DNA by interacting with its ETS domain.

About this Structure

1BC7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins., Mo Y, Vaessen B, Johnston K, Marmorstein R, Mol Cell. 1998 Aug;2(2):201-12. PMID:9734357 Page seeded by OCA on Fri May 2 11:19:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1bc7&oldid=321151"