WWP2: Difference between revisions

Line 9:

[[Image:WWP2 Scheme from paper fig 1A top.png|300px|right|thumb| WWP2 Scheme without C2 Domain]]

[[Image:WWP2 Scheme from paper D3.png|300px|right|thumb| WWP2 Scheme WW2-2,3-linker-HECT]]

Full-length WWP2 consists of an amino terminal C2 domain, four WW domains (labeled WW1-WW4) and a carboxy terminal HECT domain. WW domains are one of the smallest protein modules, consisting of less than 40 amino acids, and are characterized by two highly conserved <scene name='84/848928/Trpsinww2/1'>Tryptophan residues</scene> 20-22 residues apart along with high affinity for proline-rich motifs. Linkers of varying length connect the C2 domain to WW1, WW1 to WW2, WW2 to WW3, WW3 to WW4, and WW4 to the HECT domain. A chimeric <scene name='84/848928/Overallcolored/9'>structure</scene> of WWP2 consisting of the WW2 domain, the WW2-WW3 linker (2,3-linker), and the HECT domain is shown on the right.

Full-length WWP2 consists of an amino terminal C2 domain, four WW domains (labeled WW1-WW4) and a carboxy terminal HECT domain. WW domains are one of the smallest protein modules, consisting of less than 40 amino acids, and are characterized by two highly conserved <scene name='84/848928/Trpsinww2/1'>Tryptophan residues</scene> 20-22 residues apart along with high affinity for proline-rich motifs. Linkers of varying length connect the C2 domain to WW1, WW1 to WW2, WW2 to WW3, WW3 to WW4, and WW4 to the HECT domain. A chimeric <scene name='84/848928/Overallcolored/10'>structure</scene> of WWP2 consisting of the WW2 domain, the WW2-WW3 linker (2,3-linker), and the HECT domain is shown on the right.

The <scene name='84/848928/Linkeronly/1'>2,3-linker</scene> is alpha helical in shape. The <scene name='84/848928/Ww2_domain/8'>WW2</scene> domain is a 3 stranded beta sheet.

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@@ Line 9: / Line 9: @@
 [[Image:WWP2 Scheme from paper fig 1A top.png|300px|right|thumb| WWP2 Scheme without C2 Domain]]
 [[Image:WWP2 Scheme from paper D3.png|300px|right|thumb| WWP2 Scheme WW2-2,3-linker-HECT]]
-Full-length WWP2 consists of an amino terminal C2 domain, four WW domains (labeled WW1-WW4) and a carboxy terminal HECT domain. WW domains are one of the smallest protein modules, consisting of less than 40 amino acids, and are characterized by two highly conserved <scene name='84/848928/Trpsinww2/1'>Tryptophan residues</scene> 20-22 residues apart along with high affinity for proline-rich motifs. Linkers of varying length connect the C2 domain to WW1, WW1 to WW2, WW2 to WW3, WW3 to WW4, and WW4 to the HECT domain. A chimeric <scene name='84/848928/Overallcolored/9'>structure</scene> of WWP2 consisting of the WW2 domain, the WW2-WW3 linker (2,3-linker), and the HECT domain is shown on the right.
+Full-length WWP2 consists of an amino terminal C2 domain, four WW domains (labeled WW1-WW4) and a carboxy terminal HECT domain. WW domains are one of the smallest protein modules, consisting of less than 40 amino acids, and are characterized by two highly conserved <scene name='84/848928/Trpsinww2/1'>Tryptophan residues</scene> 20-22 residues apart along with high affinity for proline-rich motifs. Linkers of varying length connect the C2 domain to WW1, WW1 to WW2, WW2 to WW3, WW3 to WW4, and WW4 to the HECT domain. A chimeric <scene name='84/848928/Overallcolored/10'>structure</scene> of WWP2 consisting of the WW2 domain, the WW2-WW3 linker (2,3-linker), and the HECT domain is shown on the right.
 The <scene name='84/848928/Linkeronly/1'>2,3-linker</scene> is alpha helical in shape. The <scene name='84/848928/Ww2_domain/8'>WW2</scene> domain is a 3 stranded beta sheet.