WWP2: Difference between revisions
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== Relevance == | == Relevance == | ||
Mutations in the NEDD4 family of proteins have been associated with several cancers and immune disorders. Many of these mutations occur in the 2,3-linker/HECT autoinhibited domains and the modified activity of the E3 Ligases as a result of these mutations can lead to an increase in the growth of tumor cells. WWP2 may play a role in the regulation of oncogenic signaling pathways through interactions with its substrate [[PTEN]], a tumor suppressor in the [[PI3K]] pathway. The downregulation of voltage-gated sodium channels by WWP2 and other members of the NEDD4 family is an active area of research. | Mutations in the NEDD4 family of proteins have been associated with several cancers and immune disorders. Many of these mutations occur in the 2,3-linker/HECT autoinhibited domains and the modified activity of the E3 Ligases as a result of these mutations can lead to an increase in the growth of tumor cells. WWP2 may play a role in the regulation of oncogenic signaling pathways through interactions with its substrate [[PTEN]], a tumor suppressor in the [[PI3K]] pathway. The downregulation of voltage-gated sodium channels by WWP2 and other members of the NEDD4 family is an active area of research. Other known targets of WWP2 include Smads, Oct4, EGR2, and TIRF. | ||
== References == | == References == | ||
<references/> | <references/> | ||
1. Chen, | 1. Chen, W.; Jiang, X.; Luo, Z. WWP2: A Multifunctional Ubiquitin Ligase Gene. Pathol. Oncol. Res. 2014, 20 (4), 799–803. https://doi.org/10.1007/s12253-014-9838-y. | ||
2. Ingham, R.J., Gish, G., & Pawson, T.(2004) The Nedd4 family of E3 ubiquitin ligases: Functional diversity within a common modular architecture. Oncogene, 23(11), 1972-1984. doi:10.1038/sj.onc.1207436 | 2. Chen, Z., Jiang, H., Xu, W., Li, X., Dempsey, D. R., Zhang, X., . . . Cole, P. A. (2017). A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell, 66(3), 345-357. doi:10.1016/j.molcel.2017.03.020 PMID:28475870 | ||
3. Ingham, R.J., Gish, G., & Pawson, T.(2004) The Nedd4 family of E3 ubiquitin ligases: Functional diversity within a common modular architecture. Oncogene, 23(11), 1972-1984. doi:10.1038/sj.onc.1207436 | |||
