1bvs: Difference between revisions
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'''RUVA COMPLEXED TO A HOLLIDAY JUNCTION.''' | '''RUVA COMPLEXED TO A HOLLIDAY JUNCTION.''' | ||
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[[Category: Pearl, L H.]] | [[Category: Pearl, L H.]] | ||
[[Category: Roe, S M.]] | [[Category: Roe, S M.]] | ||
[[Category: | [[Category: Branch migration]] | ||
[[Category: | [[Category: Dna repair]] | ||
[[Category: | [[Category: Holliday junction resolvase component]] | ||
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Revision as of 09:00, 2 May 2008
RUVA COMPLEXED TO A HOLLIDAY JUNCTION.
Overview
Holliday junctions occur as intermediates in homologous recombination and DNA repair. In bacteria, resolution of Holliday junctions is accomplished by the RuvABC system, consisting of a junction-specific helicase complex RuvAB, which promotes branch migration, and a junction-specific endonuclease RuvC, which nicks two strands. The crystal structure of a complex between the RuvA protein of M. leprae and a synthetic four-way junction has now been determined. Rather than binding on the open surface of a RuvA tetramer as previously suggested, the DNA is sandwiched between two RuvA tetramers, which form a closed octameric shell, stabilized by a conserved tetramer-tetramer interface. Interactions between the DNA backbone and helix-hairpin-helix motifs from both tetramers suggest a mechanism for strand separation promoted by RuvA.
About this Structure
1BVS is a Single protein structure of sequence from Mycobacterium leprae. Full crystallographic information is available from OCA.
Reference
Crystal structure of an octameric RuvA-Holliday junction complex., Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH, Mol Cell. 1998 Sep;2(3):361-72. PMID:9774974 Page seeded by OCA on Fri May 2 12:00:49 2008
