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'''THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES''' | '''THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES''' | ||
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[[Category: Seidel, G.]] | [[Category: Seidel, G.]] | ||
[[Category: Weidler, M.]] | [[Category: Weidler, M.]] | ||
[[Category: | [[Category: Hormone]] | ||
[[Category: | [[Category: Human peptide hormone]] | ||
[[Category: | [[Category: Humoral hypercalcemia of malignancy]] | ||
[[Category: | [[Category: Pth]] | ||
[[Category: | [[Category: Pthrp]] | ||
[[Category: | [[Category: Serum calcium level]] | ||
[[Category: | [[Category: Solution structure]] | ||
[[Category: | [[Category: Stimulating intracellular camp formation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:09:04 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 09:09, 2 May 2008
THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES
Overview
Parathyroid hormone-related protein plays a major role in the pathogenesis of humoral hypercalcemia of malignancy. Under normal physiological conditions, parathyroid hormone-related protein is produced in a wide variety of tissues and acts in an autocrine or paracrine fashion. Parathyroid hormone-related protein and parathyroid hormone bind to and activate the same G-protein-coupled receptor. Here we present the structure of the biologically active NH2-terminal domain of human parathyroid hormone-related protein(1-34) in near-physiological solution in the absence of crowding reagents as determined by two-dimensional proton magnetic resonance spectroscopy. An improved strategy for structure calculation revealed the presence of two helices, His-5-Leu-8 and Gln-16-Leu-27, connected by a flexible linker. The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone. Thus, the similarity of the binding affinities of parathyroid hormone and parathyroid hormone-related protein to their common receptor may be based on their structural similarity.
About this Structure
1BZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution., Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P, FEBS Lett. 1999 Feb 12;444(2-3):239-44. PMID:10050767 Page seeded by OCA on Fri May 2 12:09:04 2008
