DAHP synthase

spinqualitylabelsall models E. coli DAHP synthase complex with PEP, phenylalanine, sulfate and Mn+2 ion (PDB code 1kfl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DAHP synthase or 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase or phospho-2-dehydro-3-deoxyheptonate aldolase (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate. DAHPS is part of the shikimate pathway. DAHPS requires a bivalent metal ion cofactor for normal activity. DAHPS is a tetramer. DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan. Structural highlights The DAHPS active site is located in a channel at the C-terminal of the enzyme where the substrate (PEP), inhibitor (phenylalanine) and metal ion (Mn+2) are seen. The bivalent metal is bound to a Cys-X-X-His motif. 3D Structures of DAHP synthase DAHP synthase 3D structures

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