Sandbox Reserved 431: Difference between revisions
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[[Student Projects for UMass Chemistry 423 Spring 2016]] | [[Student Projects for UMass Chemistry 423 Spring 2016]] | ||
==Introduction== | ==Introduction== | ||
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In the human body, CYP2R1, a member of the cytochrome P450 family, is responsible for the first steps of the conversion of vitamin D into a bioavailable form within the liver. CYP2R1 is also known as Vitamin D 25-hydroxylase as it hydroxylates vitamin D3 into calcidiol, the bioavailable form of the vitamin, which would then be converted to calcitriol via the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase, as seen in figure 1. | In the human body, CYP2R1, a member of the cytochrome P450 family, is responsible for the first steps of the conversion of vitamin D into a bioavailable form within the liver. CYP2R1 is also known as Vitamin D 25-hydroxylase as it hydroxylates vitamin D3 into calcidiol, the bioavailable form of the vitamin, which would then be converted to calcitriol via the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase, as seen in figure 1. | ||
[[Image:Action_Of_CYP2R1.jpg | [[Image:Action_Of_CYP2R1.jpg]] | ||
Fig. 1, the conversion of vitamin D3 into calcidiol via Vitamin D 25-hydroxylase | Fig. 1, the conversion of vitamin D3 into calcidiol via Vitamin D 25-hydroxylase | ||
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<scene name='48/483888/Human_p450/1'>Human P450 Cytochrome</scene> is shown with amino acids in teal and the heme center shown as a space filling model, with the nitrogen shown in blue, carbon in gray, oxygen in red, and the iron center shown in orange | <scene name='48/483888/Human_p450/1'>Human P450 Cytochrome</scene> is shown with amino acids in teal and the heme center shown as a space filling model, with the nitrogen shown in blue, carbon in gray, oxygen in red, and the iron center shown in orange | ||
<StructureSection load='3c6g' size='350' side='right' caption='Structure of Human Cytochrome p450' scene=''> | |||
==Overall Structure== | ==Overall Structure== | ||
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<scene name='48/483888/Hemegroup/1'>Leu99 and Arg445</scene> | <scene name='48/483888/Hemegroup/1'>Leu99 and Arg445</scene> | ||
</StructureSection> | |||
==Quiz Question 1== | ==Quiz Question 1== | ||
