Farnesyl diphosphate synthase: Difference between revisions
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[[Image:FPPSynthesisDiagram.png|700x750px]] | [[Image:FPPSynthesisDiagram.png|700x750px]] | ||
== Structure == | == Structure == | ||
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FPS <scene name='48/485622/Cv/12'>active site</scene> contains <scene name='48/485622/Cv/13'>Mg+2 ions coordination sites</scene> and binds <scene name='48/485622/Cv/11'>bisphosphonate inhibitors</scene>; see also <scene name='48/485622/Cv/14'>phosphates coordination sites</scene>, (PDB code [[2opm]])<ref>PMID:19309137</ref>, water molecules are shown as red spheres. | FPS <scene name='48/485622/Cv/12'>active site</scene> contains <scene name='48/485622/Cv/13'>Mg+2 ions coordination sites</scene> and binds <scene name='48/485622/Cv/11'>bisphosphonate inhibitors</scene>; see also <scene name='48/485622/Cv/14'>phosphates coordination sites</scene>, (PDB code [[2opm]])<ref>PMID:19309137</ref>, water molecules are shown as red spheres. | ||
==3D structures of | == Relevance == | ||
FPS bisphosphonate inhibitors (like zoledronic acid) are used as drugs for treatment of bone resorption diseases<ref>PMID:24369118</ref>. FPS inhibitor [[Alendronate]] or Fosamax is used in treatment of osteoporosis<ref>PMID:9116385</ref>. Bisphosphonates have been explored as antiparasitic drugs with FPPS because current treatments are expensive, have low efficacy, and have dangerous side effects. FPPS is important in the lengthening of hydrophobic chains and determination of their specificity. | |||
==Published 3D structures of FPPS= | |||
[[Farnesyl diphosphate synthase 3D structures]] | [[Farnesyl diphosphate synthase 3D structures]] | ||
