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==triazolopyridine inhibitors of p38 kinase==
==triazolopyridine inhibitors of p38 kinase==
<StructureSection load='2yiw' size='340' side='right' caption='[[2yiw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2yiw' size='340' side='right'caption='[[2yiw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yiw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YIW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yiw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YIW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I46:2-FLUORO-4-[4-(4-FLUOROPHENYL)-1H-PYRAZOL-3-YL]PYRIDINE'>I46</scene>, <scene name='pdbligand=YIW:1-(3-TERT-BUTYL-1-PHENYL-1H-PYRAZOL-5-YL)-3-(2-{[3-(1-METHYLETHYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YL]SULFANYL}BENZYL)UREA'>YIW</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I46:2-FLUORO-4-[4-(4-FLUOROPHENYL)-1H-PYRAZOL-3-YL]PYRIDINE'>I46</scene>, <scene name='pdbligand=YIW:1-(3-TERT-BUTYL-1-PHENYL-1H-PYRAZOL-5-YL)-3-(2-{[3-(1-METHYLETHYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YL]SULFANYL}BENZYL)UREA'>YIW</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2baj|2baj]], [[1wfc|1wfc]], [[1w7h|1w7h]], [[1wbo|1wbo]], [[1kv2|1kv2]], [[1yqj|1yqj]], [[1bmk|1bmk]], [[1bl7|1bl7]], [[1zyj|1zyj]], [[1a9u|1a9u]], [[1wbt|1wbt]], [[2i0h|2i0h]], [[2baq|2baq]], [[1wbv|1wbv]], [[1zz2|1zz2]], [[1di9|1di9]], [[1w83|1w83]], [[1bl6|1bl6]], [[1m7q|1m7q]], [[1ian|1ian]], [[1oz1|1oz1]], [[1wbn|1wbn]], [[2bak|2bak]], [[2bal|2bal]], [[1wbs|1wbs]], [[1ouk|1ouk]], [[1ouy|1ouy]], [[2y8o|2y8o]], [[2yis|2yis]], [[1r39|1r39]], [[1kv1|1kv1]], [[1wbw|1wbw]], [[1w82|1w82]], [[2yix|2yix]], [[1r3c|1r3c]], [[1ove|1ove]], [[1w84|1w84]], [[1zzl|1zzl]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2baj|2baj]], [[1wfc|1wfc]], [[1w7h|1w7h]], [[1wbo|1wbo]], [[1kv2|1kv2]], [[1yqj|1yqj]], [[1bmk|1bmk]], [[1bl7|1bl7]], [[1zyj|1zyj]], [[1a9u|1a9u]], [[1wbt|1wbt]], [[2i0h|2i0h]], [[2baq|2baq]], [[1wbv|1wbv]], [[1zz2|1zz2]], [[1di9|1di9]], [[1w83|1w83]], [[1bl6|1bl6]], [[1m7q|1m7q]], [[1ian|1ian]], [[1oz1|1oz1]], [[1wbn|1wbn]], [[2bak|2bak]], [[2bal|2bal]], [[1wbs|1wbs]], [[1ouk|1ouk]], [[1ouy|1ouy]], [[2y8o|2y8o]], [[2yis|2yis]], [[1r39|1r39]], [[1kv1|1kv1]], [[1wbw|1wbw]], [[1w82|1w82]], [[2yix|2yix]], [[1r3c|1r3c]], [[1ove|1ove]], [[1w84|1w84]], [[1zzl|1zzl]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yiw OCA], [http://pdbe.org/2yiw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yiw RCSB], [http://www.ebi.ac.uk/pdbsum/2yiw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yiw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yiw OCA], [http://pdbe.org/2yiw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yiw RCSB], [http://www.ebi.ac.uk/pdbsum/2yiw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yiw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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==See Also==
==See Also==
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Anderson, M]]
[[Category: Anderson, M]]
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