6wuw: Difference between revisions
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==Crystal structure of Human Serum Albumin complex with JMS-053== | ==Crystal structure of Human Serum Albumin complex with JMS-053== | ||
<StructureSection load='6wuw' size='340' side='right'caption='[[6wuw]]' scene=''> | <StructureSection load='6wuw' size='340' side='right'caption='[[6wuw]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WUW FirstGlance]. <br> | <table><tr><td colspan='2'>[[6wuw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WUW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuw OCA], [http://pdbe.org/6wuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wuw RCSB], [http://www.ebi.ac.uk/pdbsum/6wuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuw ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=UAY:7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione'>UAY</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuw OCA], [http://pdbe.org/6wuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wuw RCSB], [http://www.ebi.ac.uk/pdbsum/6wuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | |||
==See Also== | |||
*[[Albumin 3D structures|Albumin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cooper | [[Category: Structural genomic]] | ||
[[Category: Czub | [[Category: Cooper, D R]] | ||
[[Category: Lazo | [[Category: Czub, M P]] | ||
[[Category: Minor W]] | [[Category: Lazo, J S]] | ||
[[Category: Shabalin | [[Category: Minor, W]] | ||
[[Category: Shabalin, I G]] | |||
[[Category: Albumin]] | |||
[[Category: Csgid]] | |||
[[Category: Drug transport]] | |||
[[Category: Hsa]] | |||
[[Category: Jms-053]] | |||
[[Category: Transport protein]] | |||
Revision as of 05:58, 5 August 2020
Crystal structure of Human Serum Albumin complex with JMS-053
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