M2 protein: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[ | [[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]], [[6mpl]], [[6mpm]], [[6mpn]] - IavM2 TM – Influenza A virus<br /> | ||
[[ | [[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) <br /> | ||
[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br /> | [[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br /> | ||
[[6oug]] - IavM2 TM (mutant) + amantadine derivative<br /> | |||
[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br /> | [[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br /> | ||
[[2rlf]] - IavM2 TM +rimantadine - NMR<br /> | [[2rlf]] - IavM2 TM +rimantadine - NMR<br /> | ||
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[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br /> | [[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br /> | ||
[[4c3e]] – hrsvM2 (mutant)<br /> | [[4c3e]] – hrsvM2 (mutant)<br /> | ||
[[5nkx]] – hrsvM2 core domain <br /> | [[5nkx]] – hrsvM2 core domain 73-185<br /> | ||
[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br /> | [[2l9j]] – hrsvM2 core domain (mutant) - NMR<br /> | ||
[[6g0y]] – hrsvM2 + phosphoprotein<br /> | |||
[[6pzq]] – hrsvM2 + RNA<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:50, 3 September 2020
<StructureSection load='4c3e' size='350' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry 4c3e)' scene='45/458472/Cv/1'>
Function
The M2 protein or Matrix protein 2 (M2) is a proton selective ion channel of the influenza virus[1]. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:
M2 Proton Channel
Molecular Playground/Influenza A M2 transmembrane domain
M2 Proton Channel Inhibitor Pharmacokinetics.
Structural highlights
M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain[2]. Zn binding site.
3D structures of M2 protein
Updated on 03-September-2020
3bkd, 5um1, 5ttc, 5joo, 4qkm, 4qkl, 4qkc, 4qk7, 6mpl, 6mpm, 6mpn - IavM2 TM – Influenza A virus
3lbw, 5c02, 4rwc, 4rwb – IavM2 TM (mutant)
3c9j, 6bkk, 6bmz - IavM2 TM + amantadine derivative
6oug - IavM2 TM (mutant) + amantadine derivative
6bkl, 6boc - IavM2 TM + rimantadine
2rlf - IavM2 TM +rimantadine - NMR
2kqt, 1mp6, 1nyj, 2h95 - IavM2 TM – NMR
2kih, 2kwx, 2l0j - IavM2 TM (mutant) – NMR
2ljb, 2ljc - IavM2 TM (mutant)/IbvM2 TM – NMR
2kix - IbvM2 TM (mutant) – Influenza B virus – NMR
2kj1 – IbvM2 cytoplasmic domain - NMR
4c3b, 4c3d – hrsvM2 – Human respiratory syncytial virus
4c3e – hrsvM2 (mutant)
5nkx – hrsvM2 core domain 73-185
2l9j – hrsvM2 core domain (mutant) - NMR
6g0y – hrsvM2 + phosphoprotein
6pzq – hrsvM2 + RNA
References
- ↑ Betakova T. M2 protein-a proton channel of influenza A virus. Curr Pharm Des. 2007;13(31):3231-5. PMID:18045172
- ↑ Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincao J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eleouet JF, Edwards TA, Barr JN. Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A. 2014 Jan 16. PMID:24434552 doi:https://dx.doi.org/10.1073/pnas.1317262111
