Insulin: Difference between revisions
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Undo revision 3288318 by Karsten Theis (Talk) |
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== Structure == | == Structure == | ||
<StructureSection load='' size='350' side='right' scene='82/821037/Ribbon/1' caption=''> | <StructureSection load='' size='350' side='right' scene='82/821037/Ribbon/1' caption=''> | ||
===Structure of mature insulin monomer=== | ===Structure of mature insulin monomer=== | ||
Mature insulin (<scene name='82/821037/Ribbon/1'>reload initial figure</scene>) contains two chains, A <jmol> | Mature insulin (<scene name='82/821037/Ribbon/1'>reload initial figure</scene>) contains two chains, A <jmol> | ||
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</jmol>, structural elements that are far apart in the unliganded conformation. Thus, binding of insulin in site 1 requires a large structural rearrangement that activates the tyrosine kinase activity of the endodomain by bringing the two kinase domains close for autophosphorylation. | </jmol>, structural elements that are far apart in the unliganded conformation. Thus, binding of insulin in site 1 requires a large structural rearrangement that activates the tyrosine kinase activity of the endodomain by bringing the two kinase domains close for autophosphorylation. | ||
</StructureSection> | |||
==Insulin 3D structures== | ==Insulin 3D structures== | ||
