Sandbox GGC1: Difference between revisions

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'''Histone chaperone ASF1A'''
'''Histone H3.3'''
<StructureSection load='ASF1A' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='ASF1A' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Sandbox GGC1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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== Function ==  
== Function ==  
[https://www.uniprot.org/uniprot/Q9Y294]. Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit
[https://www.uniprot.org/uniprot/P84243]. The Variant  [https://www.uniprot.org/uniprot/P84243 histone H3] replaces H3 in a range of nucleosomes in active genes. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
== Disease ==
== Disease ==


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