7jrh: Difference between revisions

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==X-ray crystal structure of a cyclic peptide containing medin(19-25) and medin(31-37)==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br>

<table><tr><td colspan='2'>[[7jrh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [http://pdbe.org/7jrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [http://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [http://pdbe.org/7jrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [http://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Amyloidogenic peptides and proteins are rich sources of supramolecular assemblies. Sequences derived from well-known amyloids, including Abeta, human islet amyloid polypeptide, and tau have been found to assemble as fibrils, nanosheets, ribbons, and nanotubes. The supramolecular assembly of medin, a 50-amino acid peptide that forms fibrillary deposits in aging human vasculature, has not been heavily investigated. In this work, we present an X-ray crystallographic structure of a cyclic beta-sheet peptide derived from the 19-36 region of medin that assembles to form interpenetrating cubes. The edge of each cube is composed of a single peptide, and each vertex is occupied by a divalent metal ion. This structure may be considered a metal-organic framework (MOF) containing a large peptide ligand. This work demonstrates that peptides containing Glu or Asp that are preorganized to adopt beta-hairpin structures can serve as ligands and assemble with metal ions to form MOFs.

Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36.,Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS J Am Chem Soc. 2020 Sep 3. doi: 10.1021/jacs.0c06143. PMID:32816461<ref>PMID:32816461</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Howitz WJ]]

[[Category: Howitz, W J]]

[[Category: Nowick JS]]

[[Category: Nowick, J S]]

[[Category: Wierzbicki M]]

[[Category: Wierzbicki, M]]

[[Category: Cyclic]]

[[Category: De novo protein]]

[[Category: Framework]]

[[Category: Hairpin]]

[[Category: Medin]]

[[Category: Mof]]

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 ==X-ray crystal structure of a cyclic peptide containing medin(19-25) and medin(31-37)==
-<StructureSection load='7jrh' size='340' side='right'caption='[[7jrh]]' scene=''>
+<StructureSection load='7jrh' size='340' side='right'caption='[[7jrh]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7jrh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [http://pdbe.org/7jrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [http://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [http://pdbe.org/7jrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [http://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr>
 </table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Amyloidogenic peptides and proteins are rich sources of supramolecular assemblies. Sequences derived from well-known amyloids, including Abeta, human islet amyloid polypeptide, and tau have been found to assemble as fibrils, nanosheets, ribbons, and nanotubes. The supramolecular assembly of medin, a 50-amino acid peptide that forms fibrillary deposits in aging human vasculature, has not been heavily investigated. In this work, we present an X-ray crystallographic structure of a cyclic beta-sheet peptide derived from the 19-36 region of medin that assembles to form interpenetrating cubes. The edge of each cube is composed of a single peptide, and each vertex is occupied by a divalent metal ion. This structure may be considered a metal-organic framework (MOF) containing a large peptide ligand. This work demonstrates that peptides containing Glu or Asp that are preorganized to adopt beta-hairpin structures can serve as ligands and assemble with metal ions to form MOFs.
+Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36.,Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS J Am Chem Soc. 2020 Sep 3. doi: 10.1021/jacs.0c06143. PMID:32816461<ref>PMID:32816461</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 7jrh" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Howitz WJ]]
+[[Category: Howitz, W J]]
-[[Category: Nowick JS]]
+[[Category: Nowick, J S]]
-[[Category: Wierzbicki M]]
+[[Category: Wierzbicki, M]]
+[[Category: Cyclic]]
+[[Category: De novo protein]]
+[[Category: Framework]]
+[[Category: Hairpin]]
+[[Category: Medin]]
+[[Category: Mof]]