5uze: Difference between revisions
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==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182== | |||
<StructureSection load='5uze' size='340' side='right'caption='[[5uze]], [[Resolution|resolution]] 2.27Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5uze]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clop1 Clop1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UZE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L1:N-{4-CHLORO-3-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]PHENYL}-N-(2-{3-[(1E)-N-HYDROXYETHANIMIDOYL]PHENYL}PROPAN-2-YL)UREA'>8L1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q32|4q32]], [[4q33|4q33]], [[5uwx|5uwx]], [[5uxe|5uxe]], [[5uzc|5uzc]], [[5uzo|5uzo]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, CPF_2558 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195103 CLOP1])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uze OCA], [http://pdbe.org/5uze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uze RCSB], [http://www.ebi.ac.uk/pdbsum/5uze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uze ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A0H2YRZ7_CLOP1 A0A0H2YRZ7_CLOP1]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | |||
==See Also== | |||
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Clop1]] | ||
[[Category: | [[Category: IMP dehydrogenase]] | ||
[[Category: Large Structures]] | |||
[[Category: Anderson, W F]] | |||
[[Category: Structural genomic]] | |||
[[Category: Gollapalli, D R]] | |||
[[Category: Gu, M]] | |||
[[Category: Hedstrom, L]] | |||
[[Category: Joachimiak, A]] | |||
[[Category: Kim, Y]] | |||
[[Category: Makowska-Grzyska, M]] | [[Category: Makowska-Grzyska, M]] | ||
[[Category: Maltseva, N]] | [[Category: Maltseva, N]] | ||
[[Category: | [[Category: Mulligan, R]] | ||
[[Category: | [[Category: Csgid]] | ||
[[Category: | [[Category: Impdh]] | ||
[[Category: | [[Category: Oxidoreductase]] | ||
[[Category: | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
[[Category: | [[Category: Tim barrel]] | ||
Revision as of 08:27, 30 September 2020
Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182
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