User:Jordan Scott/Sandbox RNA polII: Difference between revisions
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While RNAP II is capable of transcription by itself it is non-selective of any particular DNA region. However some mutageneis studies have shown that RNAP II may have some role in selectivity.<ref name="rich"/> To properly recognize regions upstream of the gene's transcription start site it requires several general transcription factors that are selective for these regions known as promoters and positions RNAP to accurately begin transcription.<ref name="meyers"/> (B) There are other accessory proteins that regulate the rate of transcription based on environmental factors.<ref name="txn">RNA polymerase II transcription initiation: A structural view | While RNAP II is capable of transcription by itself it is non-selective of any particular DNA region. However some mutageneis studies have shown that RNAP II may have some role in selectivity.<ref name="rich"/> To properly recognize regions upstream of the gene's transcription start site it requires several general transcription factors that are selective for these regions known as promoters and positions RNAP to accurately begin transcription.<ref name="meyers"/> (B) There are other accessory proteins that regulate the rate of transcription based on environmental factors.<ref name="txn">RNA polymerase II transcription initiation: A structural view | ||
D. B. Nikolov, S. K. Burley Proceedings of the National Academy of Sciences Jan 1997, 94 (1) 15-22; DOI: 10.1073/pnas.94.1.15</ref> These GTF's and | D. B. Nikolov, S. K. Burley Proceedings of the National Academy of Sciences Jan 1997, 94 (1) 15-22; DOI: 10.1073/pnas.94.1.15</ref> These GTF's and accessory proteins are necessary for accurate transcription and together with the RNAP II core enzyme form the RNAP holoenzyme. | ||
