Phosphoglucoisomerase: Difference between revisions
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'''Step 5.''' Lys518 (or His388b) abstracts back the proton from the sugar ring oxygen, resulting in a ring closure, to give the product. | '''Step 5.''' Lys518 (or His388b) abstracts back the proton from the sugar ring oxygen, resulting in a ring closure, to give the product. | ||
[[Image:Fig 15-3 2014 1420.png| | [[Image:Fig 15-3 2014 1420.png|900px|left|thumb| '''Figure 3.''' The reaction mechanism of phosphoglucosisomerase. The active site catalytic residues, BH<sup>+</sup> and B′, are thought to be Lys and His, respectively.<ref>''Fundamentals of Biochemistry | ||
Life at the Molecular Level'' Vth Edition (2016), Donald Voet, Judith G. Voet Charlotte W. Pratt; Fig 15-3, pg 483.</ref>]] | Life at the Molecular Level'' Vth Edition (2016), Donald Voet, Judith G. Voet Charlotte W. Pratt; Fig 15-3, pg 483.</ref>]] | ||
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=='''Regulation and Inhibition'''== | =='''Regulation and Inhibition'''== | ||
'''Regulation''' of phosphoglucoisomerase is only done by the relative concentrations of glucose-6-phosphate and fructose 6-phosphate, towards equilibrium. Nevertheless, it was found that the kinetic parameters of PGI does depend on the pH and temperature of the environment. | '''Regulation''' of phosphoglucoisomerase is only done by the relative concentrations of glucose-6-phosphate and fructose 6-phosphate, towards equilibrium. Nevertheless, it was found that the kinetic parameters of PGI does depend on the pH and temperature of the environment. | ||
