Sandbox GGC11: Difference between revisions
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== Relevance == | == Relevance == | ||
Alpha Crystallin A 1-172 is found at nearly 2 folds higher in diabetic lenses than an aged matched control lens. In humans, the alpha A gene is found in chromosome 21 and encodes for 173 amino acid residues while the alpha B gene is found in chromosome 11 and encodes for 175 amino acids.<ref name="alpha" /> In mammalian lens, the molar ratio between alpha A and alpha B is a 3 to 1 ratio. <ref>PMID:20836128</ref> | Alpha Crystallin A 1-172 is found at nearly 2 folds higher in diabetic lenses than an aged matched control lens. In humans, the alpha A gene is found in chromosome 21 and encodes for 173 amino acid residues while the alpha B gene is found in chromosome 11 and encodes for 175 amino acids.<ref name="alpha" /> In mammalian lens, the molar ratio between alpha A and alpha B is a 3 to 1 ratio. <ref>PMID:20836128</ref> | ||
An increased level of Alpha Crystallin B chain has been associated with various diseases such Alexander's disease, Alzheimer's, and Parkinson's. <ref>PMID:8256860</ref> | |||
== Structural highlights == | == Structural highlights == | ||
