Sandbox GGC11: Difference between revisions
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=='''Alpha- Crystallin AB Chain'''== | =='''Alpha- Crystallin AB Chain'''== | ||
<StructureSection load='2KRL' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='2KRL' size='340' side='right' caption='Caption for this structure' scene=''> | ||
Alpha A and Alpha B Crystallin are proteins that encoded by the genes CRYAA and CRYAB. Alpha A and B are a major protein component of the mammalian eye lens. Alpha A crystallin is mainly found on the lens of the eye with trace amounts in other tissues while Alpha B is essentially considered a ubiquitous protein. <ref name= "alpha">PMID:12565801</ref> | Alpha A and Alpha B Crystallin are proteins that encoded by the genes CRYAA and CRYAB. Alpha A and B are a major protein component of the mammalian eye lens. Alpha A crystallin is mainly found on the lens of the eye with trace amounts in other tissues while Alpha B is essentially considered a ubiquitous protein. <ref name= "alpha">PMID:12565801</ref> Alpha Crystallin is part of the small heat- shock protein family that has a conserved homologous sequence of 90 to 100 residues <ref>PMID: 8450753</ref> | ||
== Function == | == Function == | ||
This protein contributes to the transparency and refractive index of the eye lens. Alpha- Crystallin can act as chaperones preventing the aggregation of various proteins. Even though they act as molecular chaperones, they don't renature proteins and release them like true chaperones do; instead, they hold proteins in large soluble aggregates. <ref>PMID:2255369</ref> Also, it has been shown that Alpha B chain is involved in the inhibition of apoptosis <ref>PMID:24725344</ref> | This protein contributes to the transparency and refractive index of the eye lens. Alpha- Crystallin can act as chaperones preventing the aggregation of various proteins. Even though they act as molecular chaperones, they don't renature proteins and release them like true chaperones do; instead, they hold proteins in large soluble aggregates. <ref>PMID:2255369</ref> Also, it has been shown that Alpha B chain is involved in the inhibition of apoptosis <ref>PMID:24725344</ref> | ||
