Sandbox GGC12: Difference between revisions

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This is a default text for your page '''Sandbox GGC12'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia <ref>PMID:12539043</ref> or to the article describing Jmol <ref>PMID:22579623~~</ref> <ref>PMID:12471095</ref> <ref>PMID:17872438~~</ref> to the rescue.

You may include any references to papers as in: the use of JSmol in Proteopedia <ref>PMID:12539043</ref> or to the article describing Jmol <ref>PMID:22579623</ref> to the rescue.

== Function ==

Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.

== Disease ==

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome.

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome <ref>PMID:17872438</ref>.

== Relevance ==

TRIF pathway

Sandbox GGC12: Difference between revisions

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 <StructureSection load='3ULS' size='340' side='right' caption='Crystal Structure of Fab12' scene=''>
 This is a default text for your page '''Sandbox GGC12'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>PMID:12539043</ref> or to the article describing Jmol <ref>PMID:22579623</ref> <ref>PMID:12471095</ref> <ref>PMID:17872438</ref> to the rescue.
+You may include any references to papers as in: the use of JSmol in Proteopedia <ref>PMID:12539043</ref> or to the article describing Jmol <ref>PMID:22579623</ref> to the rescue.
 == Function ==
-Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
+Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.
 == Disease ==
-A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
+A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome <ref>PMID:17872438</ref>.
 == Relevance ==
 TRIF pathway