Sandbox GGC12: Difference between revisions

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== Function ==

Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.

Controls the host immune response system against any pathogens through the recognition of molecular patterns tahat are specific to each microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.

== Disease ==

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome <ref>PMID:17872438</ref>.

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TRIF pathway

Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activator of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound‐repair processes.

Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activator of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound‐repair processes <ref>DOI 10.1189/jlb.2RI1115-531R.

TICAM1

Sandbox GGC12: Difference between revisions

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@@ Line 5: / Line 5: @@
 == Function ==
-Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.
+Controls the host immune response system against any pathogens through the recognition of molecular patterns tahat are specific to each microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response <ref>PMID:12471095</ref>.
 == Disease ==
 A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome <ref>PMID:17872438</ref>.
@@ Line 11: / Line 11: @@
 TRIF pathway
-Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activator of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound‐repair processes.
+Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activator of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound‐repair processes <ref>DOI 10.1189/jlb.2RI1115-531R.
 TICAM1