Sandbox GGC11: Difference between revisions
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This structure shows <scene name='78/781195/Lys72/2'>Lys 72</scene>. When this amino acid is acetylated, there might be an increase the chaperone activity for the protein. Chaperon activity is highly necessary because it plays a critical role in maintaining lens transparency. <ref>PMID:22120592</ref> | This structure shows <scene name='78/781195/Lys72/2'>Lys 72</scene>. When this amino acid is acetylated, there might be an increase the chaperone activity for the protein. Chaperon activity is highly necessary because it plays a critical role in maintaining lens transparency. <ref>PMID:22120592</ref> | ||
This structure highlights <scene name='78/781195/Asp/1'>Asp 109</scene>. A mutation of asp to his is associated with restrictive cardiomyopathy and aggregation of CRYAB and DES gene. This mutation reduces the localization of Desmin and alpha crystallin b in the Z band and intercalated disc of the myocardium. <ref>PMID: 28493373</ref>. Also, when asp 109 is mutated to his is associated with myofibrillar myopathy and polar cataracts. <ref>PMID: 21920752</ref> | This structure highlights <scene name='78/781195/Asp/1'>Asp 109</scene>. A mutation of asp 109 to his is associated with restrictive cardiomyopathy and aggregation of CRYAB and DES gene. This mutation reduces the localization of Desmin and alpha crystallin b in the Z band and intercalated disc of the myocardium. <ref>PMID: 28493373</ref>. Also, when asp 109 is mutated to his is associated with myofibrillar myopathy and polar cataracts. <ref>PMID: 21920752</ref> | ||
The following structure shows <scene name='78/781195/Crystallin/1'>Alpha Crystallin Structure</scene> with all the chains that make it up. | The following structure shows <scene name='78/781195/Crystallin/1'>Alpha Crystallin Structure</scene> with all the chains that make it up. | ||
