Sandbox GGC7: Difference between revisions
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==Insulin Protease (Insulin Degrading Enzyme)== | ==Insulin Protease (Insulin Degrading Enzyme)== | ||
<StructureSection load=' | <StructureSection load='2G54' size='340' side='right' caption='Caption for this structure' scene='Insulin Protease Dimer'> | ||
Insulin is a hormone that is secreted by the pancreas in response to an increased level of glucose in the blood, usually after a meal. Insulin stimulates the muscles and adipose tissue to take up and convert it to energy or to store the excess glucose. <scene name='75/752270/Insulin_n_to_c_terminus_rainbo/1'>Insulin</scene> is a dipeptide that contains a A and B chain. The A chain has an N-terminal helix linked to an anti-parallel C-terminal helix. The B chain has a central helical segment. The two chains are connected by 3 di-sulfide bonds that join the N- and C-terminal helices of the A chain to the central helix of the B chain <ref>PMID: 16278749</ref>. When the concentration of glucose in the blood drops, insulin is no longer needed and an insulin-degrading enzyme is produced in order to reduce the amount of insulin in the body. | Insulin is a hormone that is secreted by the pancreas in response to an increased level of glucose in the blood, usually after a meal. Insulin stimulates the muscles and adipose tissue to take up and convert it to energy or to store the excess glucose. <scene name='75/752270/Insulin_n_to_c_terminus_rainbo/1'>Insulin</scene> is a dipeptide that contains a A and B chain. The A chain has an N-terminal helix linked to an anti-parallel C-terminal helix. The B chain has a central helical segment. The two chains are connected by 3 di-sulfide bonds that join the N- and C-terminal helices of the A chain to the central helix of the B chain <ref>PMID: 16278749</ref>. When the concentration of glucose in the blood drops, insulin is no longer needed and an insulin-degrading enzyme is produced in order to reduce the amount of insulin in the body. | ||
