Sandbox GGC7: Difference between revisions

Line 3:

Insulin is a hormone that is secreted by the pancreas in response to an increased level of glucose in the blood, usually after a meal. Insulin stimulates the muscles and adipose tissue to take up and convert it to energy or to store the excess glucose. <scene name='75/752270/Insulin_n_to_c_terminus_rainbo/1'>Insulin</scene> is a dipeptide that contains a A and B chain. The A chain has an N-terminal helix linked to an anti-parallel C-terminal helix. The B chain has a central helical segment. The two chains are connected by 3 di-sulfide bonds that join the N- and C-terminal helices of the A chain to the central helix of the B chain <ref>PMID: 16278749</ref>. When the concentration of glucose in the blood drops, insulin is no longer needed and an insulin-degrading enzyme is produced in order to reduce the amount of insulin in the body.

The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/~~Ide_with_insulin_b~~/2'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>. IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain. Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH. It can be located in red blood cells, skeletal muscle, liver and brain.

The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/Ide_with_zinc_ion/1'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>. IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain. Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH. It can be located in red blood cells, skeletal muscle, liver and brain.

== Structure ==

Sandbox GGC7: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 3: / Line 3: @@
 Insulin is a hormone that is secreted by the pancreas in response to an increased level of glucose in the blood, usually after a meal.  Insulin stimulates the muscles and adipose tissue to take up and convert it to energy or to store the excess glucose.  <scene name='75/752270/Insulin_n_to_c_terminus_rainbo/1'>Insulin</scene> is a dipeptide that contains a A and B chain.  The A chain has an N-terminal helix linked to an anti-parallel C-terminal helix.  The B chain has a central helical segment.  The two chains are connected by 3 di-sulfide bonds that join the N- and C-terminal helices of the A chain to the central helix of the B chain <ref>PMID: 16278749</ref>.  When the concentration of glucose in the blood drops, insulin is no longer needed and an insulin-degrading enzyme is produced in order to reduce the amount of insulin in the body.
-The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/Ide_with_insulin_b/2'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>.  IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain.  Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH.  It can be located in red blood cells, skeletal muscle, liver and brain.
+The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/Ide_with_zinc_ion/1'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>.  IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain.  Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH.  It can be located in red blood cells, skeletal muscle, liver and brain.
 == Structure ==