Sandbox GGC1: Difference between revisions
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There have been studies that have identified mutations encoding a K27M substitution and there have also been mutations that encoded | There have been studies that have identified mutations encoding a K27M substitution and there have also been mutations that encoded | ||
GLY 34 to ARG or VAL called the G34R/V substitution. K27M tumors are present in ex: spinal cord, thalamus, pons, brainstem and G34R/V tumors are shown in the cerebral hemispheres. There are mutations in H3.3 that are found in different types of bone tumors like [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446520/ chrondroblastoma] for example and giant cell tumors of the bone. [https://cancerdiscovery.aacrjournals.org/content/3/12/1329.1 Chondroblastoma]arises in children and in young adults in the cartilage of the growth plates of the long bones and is most typically benign. | GLY 34 to ARG or VAL called the G34R/V substitution. K27M tumors are present in ex: spinal cord, thalamus, pons, brainstem and G34R/V tumors are shown in the cerebral hemispheres. There are mutations in H3.3 that are found in different types of bone tumors like [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446520/ chrondroblastoma] for example and giant cell tumors of the bone. [https://cancerdiscovery.aacrjournals.org/content/3/12/1329.1 Chondroblastoma]arises in children and in young adults in the cartilage of the growth plates of the long bones and is most typically benign. | ||
[[Image:Glioma_2018_1_4_117_240231_f1.jpg]] | [[Image:Glioma_2018_1_4_117_240231_f1.jpg]] | ||
