6mxq: Difference between revisions
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==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation== | ==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation== | ||
<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]]' scene=''> | <StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[6mxq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Specialized translation initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs. Similar to internal ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recognition by eIF3d, a new 5'-m(7)GTP recognizing protein. How these RNA structures mediate eIF3 recruitment to affect translation of specific mRNAs remains unclear. Here, we report the nuclear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and essential for specialized translation initiation of this well-known oncogene. The structure exhibits similarity to eIF3 recognizing motifs found in hepatitis C virus (HCV)-like IRESs, suggesting mechanistic similarities. This work establishes the RNA structural features involved in c-JUN specialized translation initiation and provides a basis to search for small molecule inhibitors of aberrant expression of the proto-oncogenic c-JUN. | |||
Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.,Walker MJ, Shortridge MD, Albin DD, Cominsky LY, Varani G J Mol Biol. 2020 Mar 27;432(7):1841-1855. doi: 10.1016/j.jmb.2020.01.001. Epub, 2020 Jan 14. PMID:31953146<ref>PMID:31953146</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6mxq" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Shortridge M]] | [[Category: Shortridge, M]] | ||
[[Category: Varani G]] | [[Category: Varani, G]] | ||
[[Category: Walker M]] | [[Category: Walker, M]] | ||
[[Category: C-jun]] | |||
[[Category: Cap-dependent]] | |||
[[Category: Eif3]] | |||
[[Category: Mrna]] | |||
[[Category: Rna]] | |||
[[Category: Specialized translation initiation]] | |||
