6rc9: Difference between revisions
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== | ==P1 Mycoplasma pneumoniae== | ||
<StructureSection load='6rc9' size='340' side='right'caption='[[6rc9]]' scene=''> | <StructureSection load='6rc9' size='340' side='right'caption='[[6rc9]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RC9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RC9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6rc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycpn Mycpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RC9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RC9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rc9 OCA], [http://pdbe.org/6rc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rc9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rc9 ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mgpA, MPN_141, MP013 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272634 MYCPN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rc9 OCA], [http://pdbe.org/6rc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rc9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rc9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ADP1_MYCPN ADP1_MYCPN]] The protein is the major adhesin mediating the attachment of this mycoplasma to respiratory epithelium. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane adhesion complex. Here we report the structure of P1, determined by X-ray crystallography and cryo-electron microscopy, and the X-ray structure of P40/P90. Contrary to what had been suggested, the binding site for sialic acid was found in P40/P90 and not in P1. Genetic and clinical variability concentrates on the N-terminal domain surfaces of P1 and P40/P90. Polyclonal antibodies generated against the mostly conserved C-terminal domain of P1 inhibited adhesion of M. pneumoniae, and serology assays with sera from infected patients were positive when tested against this C-terminal domain. P40/P90 also showed strong reactivity against human infected sera. The architectural elements determined for P1 and P40/P90 open new possibilities in vaccine development against M. pneumoniae infections. | |||
Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.,Vizarraga D, Kawamoto A, Matsumoto U, Illanes R, Perez-Luque R, Martin J, Mazzolini R, Bierge P, Pich OQ, Espasa M, Sanfeliu I, Esperalba J, Fernandez-Huerta M, Scheffer MP, Pinyol J, Frangakis AS, Lluch-Senar M, Mori S, Shibayama K, Kenri T, Kato T, Namba K, Fita I, Miyata M, Aparicio D Nat Commun. 2020 Oct 14;11(1):5188. doi: 10.1038/s41467-020-18777-y. PMID:33057023<ref>PMID:33057023</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6rc9" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aparicio D]] | [[Category: Mycpn]] | ||
[[Category: Fita I]] | [[Category: Aparicio, D]] | ||
[[Category: Illanes R]] | [[Category: Fita, I]] | ||
[[Category: Vizarraga D]] | [[Category: Illanes, R]] | ||
[[Category: Vizarraga, D]] | |||
[[Category: Adhesin]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Extracellular]] | |||
[[Category: Immunodominant protein]] | |||
[[Category: Transmembrane-complex]] | |||
