6twp: Difference between revisions
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==Binding domain of BoNT/A5== | ==Binding domain of BoNT/A5== | ||
<StructureSection load='6twp' size='340' side='right'caption='[[6twp]]' scene=''> | <StructureSection load='6twp' size='340' side='right'caption='[[6twp]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TWP FirstGlance]. <br> | <table><tr><td colspan='2'>[[6twp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TWP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6twp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6twp OCA], [http://pdbe.org/6twp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6twp RCSB], [http://www.ebi.ac.uk/pdbsum/6twp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6twp ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bont/A5, boNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6twp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6twp OCA], [http://pdbe.org/6twp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6twp RCSB], [http://www.ebi.ac.uk/pdbsum/6twp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6twp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (HC ), a translocation domain (HN ), and a catalytic domain (LC). Here we present high-resolution crystal structures of the binding domains of BoNT subtypes /A5 (HC /A5) and /A6 (HC /A6). These structures show that the core fold identified in other subtypes is maintained, but with subtle differences at the expected receptor binding sites. | |||
High resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.,Davies JR, Britton A, Liu SM, Acharya KR FEBS Open Bio. 2020 Jul 11. doi: 10.1002/2211-5463.12931. PMID:32654405<ref>PMID:32654405</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6twp" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus botulinus van ermengem 1896]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acharya | [[Category: Acharya, K R]] | ||
[[Category: Davies | [[Category: Davies, J R]] | ||
[[Category: Binding domain]] | |||
[[Category: Botulinum neurotoxin]] | |||
[[Category: Toxin]] | |||
