6l7q: Difference between revisions
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==Crystal structure of a hypothetical protein PYCH_01220 derived from Pyrococcus yayanosii== | ==Crystal structure of a hypothetical protein PYCH_01220 derived from Pyrococcus yayanosii== | ||
<StructureSection load='6l7q' size='340' side='right'caption='[[6l7q]]' scene=''> | <StructureSection load='6l7q' size='340' side='right'caption='[[6l7q]], [[Resolution|resolution]] 1.16Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L7Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[6l7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyryc Pyryc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L7Q FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7q OCA], [http://pdbe.org/6l7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l7q RCSB], [http://www.ebi.ac.uk/pdbsum/6l7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7q ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYCH_01220 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529709 PYRYC])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7q OCA], [http://pdbe.org/6l7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l7q RCSB], [http://www.ebi.ac.uk/pdbsum/6l7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We report the crystal structure of PYCH_01220, a hypothetical protein in Pyrococcus yayanosii CH1. This protein is composed of two domains, named Domain A and Domain B. While Domain B is not significantly homologous to known protein structures, Domain A is structurally analogous to the C-terminal ribonuclease domain of Escherichia coli colicin D. Domain A has a positively charged surface patch rendered by 13 basic residues, eight arginine or lysine residues of which are evolutionarily conserved. Electrophoretic mobility shift assays showed that PYCH_01220 binds to DNA, and charge-inversion mutations on this patch negatively affect the DNA binding, suggesting that the function of PYCH_01220 might involve nucleic acid-binding via the positively charged patch. This article is protected by copyright. All rights reserved. | |||
Crystal structure of PYCH_01220 from Pyrococcus yayanosii potentially involved in binding nucleic acid.,Noh H, Jeon JH, Kim YG, Oh BH Proteins. 2020 Nov 25. doi: 10.1002/prot.26029. PMID:33236809<ref>PMID:33236809</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6l7q" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jeon J | [[Category: Pyryc]] | ||
[[Category: Noh H]] | [[Category: Jeon, J H]] | ||
[[Category: Oh B | [[Category: Noh, H]] | ||
[[Category: Oh, B H]] | |||
[[Category: Cytosolic protein]] | |||
[[Category: Hypothetical protein]] | |||
[[Category: Unknown function]] | |||
