1p65

Crystal structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus (PRRSV)

spinqualitylabelsall models 1p65, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1p65 is a 2 chain structure with sequence from Prrsv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: orf7 (PRRSV) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped RNA virus of the Arteriviridae family, genomically related to the coronaviruses. PRRSV is the causative agent of both severe and persistent respiratory disease and reproductive failure in pigs worldwide. The PRRSV virion contains a core made of the 123 amino acid nucleocapsid (N) protein, a product of the ORF7 gene. We have determined the crystal structure of the capsid-forming domain of N. The structure was solved to 2.6 A resolution by SAD methods using the anomalous signal from sulfur. The N protein exists in the crystal as a tight dimer forming a four-stranded beta sheet floor superposed by two long alpha helices and flanked by two N- and two C-terminal alpha helices. The structure of N represents a new class of viral capsid-forming domains, distinctly different from those of other known enveloped viruses, but reminiscent of the coat protein of bacteriophage MS2. Structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus.,Doan DN, Dokland T Structure. 2003 Nov;11(11):1445-51. PMID:14604534 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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