Transketolase

spinqualitylabelsall models E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code 2r8o). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Transketolase (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle. Split-gene TKT is found in the hyperthermophilic bacterium Carboxydothermus hydrogenoformans and is reconstituted from 2 separate polypeptide chains. Structural highlights The active site of TKT contains a ligand-cofactor adduct. Water molecules are shown as red spheres. Ca coordination site.

3D Structures of transketolase

Updated on 14-December-2020

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• Transketolase
  • 1trk – yTKT – yeast
  • 1ay0 – yTKT (mutant)
  • 2e6k – TKT – Thermus thermophilus
  • 3hyl – BaTKT – Bacillus anthracis
  • 3kom – TKT (mutant) – Francisella tularensis
  • 3l84 – CjTKT – Campylobacter jejuni
    
  • 3rim – TKT – Mycobacterium tuberculosis
    
  • 3uk1 – BtTKT – Burkholderia thailandensis
    
  • 4c7v - LsTKT – Lactobacillus salivarius
    
  • 4xeu - TKT – Pseudomonas aeruginosa
    
  • 5i4i, 5xry - PsTKT – Pichia stipitis
    
  • 5hgx, 5i5g - PsTKT (mutant)
    
  • 5nd6 - CrTKT – Chlamydomonas reinhardtii
    
  • 5vrb - TKT – Neisseria gonorrhoeae
    
  • 6rjc - EcTKT 1 – Escherichia coli
    
• Transketolase binary complexes
  • 3mos, 3ooy – hTKT + TPP - human
    
  • 4kxy - hTKT + TPP analog
    
  • 6ha3 - hTKT (mutant) + fructose phosphate/TPP
    
  • 6had, 6rjb - hTKT (mutant) + TDP
    
  • 1itz - TKT + TPP – maize
  • 1tka, 1tkb, 1tkc – yTKT + TPP analog
  • 1gpu - yTKT 1 + TPP derivative
  • 1qgd - EcTKT + TPP
    
  • 6tj8 - EcTKT 1 + TPP analog
    
  • 5hht - EcTKT (mutant) + TDP
    
  • 1r9j - TKT + TPP – Leishmania mexicana
    
  • 4c7x - LsTKT + TPP
    
  • 5hyv, 5x56, 5xuf, 5xvt, 5xs6 - PsTKT + TPP
    
  • 5xsa, 5xsb, 5xsm, 5xt0, 5xt4, 5xtv, 5xtx - PsTKT + TPP intermediate
    
  • 5xqk - PsTKT + xylulose-5-P
    
  • 5xqa - PsTKT + ribose-5-P
    
  • 5xps - PsTKT + erythrose-4-P
    
  • 5xrv - PsTKT + fructose-6-P
    
  • 5i51 - PsTKT (mutant) + fructose-6-P
    
  • 5xtl - PsTKT + pyrimidine derivative
    
  • 5nd5 - CrTKT + TPP
    
  • 3m49 – BaTKT + TPP
    
• Transketolase ternary complexes
  • 4kxu - hTKT + TPP + sorbitol 6-P
    
  • 4kxv, 4kxw - hTKT + TPP + xylitol 5-P
    
  • 4kxx - hTKT + TPP + seduheptulose 7-P
    
  • 1ngs - yTKT + TPP + Ca + erythrose-4-P
    
  • 3m7i, 3m6l – CjTKT + TPP + ribose 5-P
  • 3m34 - CjTKT + TPP + Ca
  • 2r5n – EcTKT 1 + TPP + ribose 5-P
    
  • 3upt,5xqa - BtTKT + TPP + ribose 5-P
    
  • 2r8o, 5xqk - EcTKT 1 + TPP + xylulose 5-P
    
  • 6tj9 - EcTKT 1 + TPP analog + xylulose 5-P
    
  • 2r8p - EcTKT 1 + TPP + fructose 6-P
    
  • 5hje - PsTKT + TPP + seduheptulose 7-P
    
  • 5i51, 5xrv, 5xu2 - PsTKT + TPP + fructose 6-P
    
  • 5xps, 5xu9 - PsTKT + TPP + erythrose 4-P
    
  • 5i5e - PsTKT (mutant) + TPP + xylulose 5-P
    
• Split-gene transketolase
  • 6yak - ChTKT N-terminal + C-terminal chain – Carboxydothermus hydrogenoformans
    
  • 6yaj - ChTKT C-terminal chain
    

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