6zfw: Difference between revisions
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==X-ray structure of the soluble N-terminal domain of T. cruzi PEX-14== | ==X-ray structure of the soluble N-terminal domain of T. cruzi PEX-14== | ||
<StructureSection load='6zfw' size='340' side='right'caption='[[6zfw]]' scene=''> | <StructureSection load='6zfw' size='340' side='right'caption='[[6zfw]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZFW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZFW FirstGlance]. <br> | <table><tr><td colspan='2'>[[6zfw]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZFW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZFW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zfw OCA], [http://pdbe.org/6zfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zfw RCSB], [http://www.ebi.ac.uk/pdbsum/6zfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zfw ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C3747_80g13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zfw OCA], [http://pdbe.org/6zfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zfw RCSB], [http://www.ebi.ac.uk/pdbsum/6zfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zfw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A2V2WKZ5_TRYCR A0A2V2WKZ5_TRYCR]] Component of the peroxisomal translocation machinery.[RuleBase:RU367032] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We develop a residual deep learning model, hotWater (https://pypi.org/project/hotWater/), to identify key water interaction sites on proteins for binding models and drug discovery. This is tested on new crystal structures, as well as cryo-EM and NMR structures from the PDB and in crystallographic refinement with promising results. | |||
Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.,Zaucha J, Softley CA, Sattler M, Frishman D, Popowicz GM Chem Commun (Camb). 2020 Nov 25. doi: 10.1039/d0cc04383d. PMID:33237041<ref>PMID:33237041</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6zfw" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ostertag | [[Category: Trycr]] | ||
[[Category: Popowicz | [[Category: Ostertag, M O]] | ||
[[Category: Sattler M]] | [[Category: Popowicz, G P]] | ||
[[Category: Softley | [[Category: Sattler, M]] | ||
[[Category: Softley, C A]] | |||
[[Category: Chagas disease]] | |||
[[Category: Glycosomal import]] | |||
[[Category: Peroxisome]] | |||
[[Category: Protein transport]] | |||
[[Category: Trypanosoma cruzi]] | |||
